Does the brain consider weight loss a threat?

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Why do most of us feel frustrated after a long journey with diet? When a person weighs himself after successfully losing weight and losing ten or twenty kilograms, only to find that he has gained them again after several months!!, his joy is lost in front of the mirror that he thinks has deceived him, when my friend, kidney professor, Amin Rushdi Suleiman, sent me his scientific article, which he published in:

Experimental and clinical endocrinology and diabetes 5 October 2026 I found some answers to these confusing questions, which I think there is still a long way to go to resolve them, but such important research is a step on the way, as it initially raises an urgent question: Why is continuing to lose weight and maintaining it so difficult? He replies: The issue is not just “will”, and hanging the gallows of blame and accusation for the obese person, and he answers that the secret may be in “the brain’s memory”!

When we gain excess weight, the center for controlling metabolism and hunger in the brain (the hypothalamus) causes profound cellular changes. His published research paper explained why it is easy to regain weight after dieting, and enumerates the reasons. First: The “self-cleaning” system in the brain malfunctions. Under normal circumstances, brain cells use a process called (autophagy) to get rid of cellular waste, but high-fat foods slow down this process and lead to inflammation and insulin resistance within the brain. Second: The formation of a “genetic memory” of obesity.

By overeating in the long term, which changes the way hunger and satiety genes are turned on or off (epigenetic modifications), even after you lose weight, this “molecular memory” remains engraved in the brain, and drives appetite to rise again, and Dr. answers. Amin in his article about the mystery of modern weight loss drugs (such as Ozembic and Semaglutide). These drugs provide excellent results throughout their use, but stopping them often leads to rapid weight regain. What is the reason mentioned in the article?

These medications actually calm brain infections, but they often cannot erase the deep genetic memory engraved in the cells. Dr. Amen to the conclusion, which is that obesity is not a weakness of will or just a mathematical equation for calories, but it is a central regulatory state linked to the brain’s memory, and future treatments for obesity will inevitably need to combine appetite suppression with erasing and resetting the brain’s “cellular memory” to ensure lasting results!